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KMID : 0367419770180060020
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Journal of Korean Pediatric Society
1977 Volume.18 No. 6 p.20 ~ p.28
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Studies on Serum Proteins by Electrophoresis in the Renal Disease
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金光井/Kim, Kwang Chung
金英嫄/金周龍/Kim, Young Won/Kim, Joo Ryong
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Abstract
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We studied serum protein fractions by Cellulose-Acetate Membrane Immitnoelectrophoresis: which were included 80 cases of acute glomerulonephritis and 7 cases of nephrotic syndrome,. and compared with 20 cases of normal healthy children as control group.
The results were as follows;
1. In 80 cases of acute glomerulonephritis, generally the distribution of serum protein fractions were summerized as follows; Albumin, al-and P-globulin were decreased ´slightly and a~-globulin increased slightly, but 7--globulin was increased markedly than control group.
Serum protein fractions were compared by severity of disease (Group I to IV): Group L showing normal or only slightly elevated BUN and blood pressure; Group II showing markedly increased BUN and decreased urinary output but normal or only slightly elevated blood pressure; Group III showing markedly increased blood pressure but normal or slightly ´elevated BUN; Group IV showing markedly increased BUN and blood pressure and diminished urinary output, and may complicate with hypertensive encephalopathy, cardiac failure and renal failure.
In Group I to III, no significant changes in fraction levels except 7-globulin which was markedly increased in Group I and M. But Group IV revealed 47.3% of Albumin for 58.2% of controlgroup, 8.4% of p-globulin for 11.7% of control group, and 29.3% of 7-globulin for 15.5% of control group.
2. In 7 cases of nephi oti(,. syndrome, total protein, albumin, al-and 7-globulin were decreased, and as -and ,B-globulin wore increased. Significant changes in serum total protein showed 5.Ogm% for 7.26.9m% of control group, and a2-globulin showed 28.7% for 9.56% of control group, which were more marked changes in nephrotic syndrome.
3. In control group, our studies for serum protein fractions were revealed almost sameas other reports.
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